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Vol. 2, No. 18, 13 September 2002
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Other Issues:
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AIDScience Perspective:
Vaccine research:
Recent data showed that covalently cross-linked complexes of the HIV-1 surface envelope glycoprotein and CD4 elicited antibodies in rhesus macaques that were able to neutralize a wide range of primary HIV isolates, regardless of their subtype or coreceptor use.
Broadly cross-reactive anti-HIV neutralizing antibodies: A conversation with Robert Gallo
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Hot News:
NeuroAIDS: SIV may hide in the brain. A simian immunodeficiency virus (SIV)/macaque model of HIV dementia was used to show that viral DNA levels in the brain remained at constant levels from acute through asymptomatic infection, despite significant down-regulation of viral RNA in the brain after the acute phase of infection.
The Journal of Infectious Diseases 186(7), 905, 1 October 2002 [Read abstract]
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Natural resistance to HIV: HIV-specific CD8+ T cell activity in uninfected injection drug users is associated with maintenance of seronegativity.
AIDS 16(12), 1595, 16 August 2002 [Read abstract]
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First viral load system to include automation. The U.S. Food and Drug Administration (FDA) approved Bayer Diagnostics' VERSANT® HIV-1 RNA 3.0 Assay, its nucleic acid probe diagnostic assay for the quantitation of HIV-1 RNA in the plasma of people living with HIV. The Bayer viral load system is the first FDA-approved viral load test that automates critical assay steps.
[See news release]
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Regional consultations for CDC's HIV Prevention Community-Based Program. The U.S. CDC plans to plan to convene four regional consultations for input to assist in determining the future funding for the Community-Based HIV Prevention Program.
[See details]
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RNA interference scores another hit. New research in a model of cervical carcinoma cells positive for human papillomavirus (HPV) type 16 demonstrated for the first time that short interfering RNA (siRNA) could selectively silence exogenous viral genes in mammalian cells. By silencing one viral gene, the tumor cells stopped growing. Silencing another gene induced apoptotic cell death. siRNA had no effect on HPV-negative cells.
Oncogene 21(39), 6041, 5 September 2002 [Read abstract]
Recent RNA interference papers related to HIV:
Nature Medicine 8(7), 659, July 2002 [Read abstract]
Nature Biotechnology 20(5), 500, May 2002 [Read abstract]
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HIV superinfection: A rare event or a major implication for vaccine research and public health? Swiss researchers have documented another case of HIV superinfection in a 38-year-old man who acquired a second strain through unprotected sex more than two years after he was first infected in 1998.
New England Journal of Medicine 340(10), 731, 5 September 2002 [Read commentary]
Recent paper on HIV superinfection:
Journal of Virology 76(15), 7444, August 2002 [Read abstract]
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IL-2 increases CD4+ cells in HIV+ patients. Adjuvant IL-2 therapy in immunologic nonresponders resulted in a clinical improvement, suggesting that the CD4+ cell recovery is not only quantitative but involves functionally competent immune cells.
The Journal of Infectious Diseases 186(5), 606, 1 September 2002 [Read abstract]
Related articles:
Blood 100(6), 2159, 15 September 2002 [Read abstract]
Proc. Natl. Acad. Sci. USA 99(16), 10712, 6 August 2002 [Read abstract]
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From Medscape:
Viral pathogenesis: HIV attachment and entry. This article by Robert W. Doms reviews the basic steps of virus entry and how each of these steps can be inhibited.
[Read article] (free one-time registration required)
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Latest News Headlines:
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Missing Chinese AIDS activist named winner of U.S.-Canadian health award. Yahoo! News. September 13, 2002
| Rising problem tied to AIDS: Increase in orphan children. Philadelphia Inquirer. September 13, 2002
| Explosive HIV Epidemic among Russian drug users. Yahoo! News. September 13, 2002
| Teens are HIV 'time bombs'. Yahoo! News. September 12, 2002
| Epidemic of ignorance. The Guardian. September 12, 2002
| HIV harnessed to save lives. The Guardian. September 12, 2002
| Condoms to be distributed free as part of Pacific nation's campaign to tackle HIV/AIDS. Yahoo! News. September 12, 2002
| Africa's AIDS victims turn to Botswana. Financial Times. September 11, 2002
| Fiji health minister warns HIV cases set to triple. Financial Times. September 11, 2002
| AIDS virus lurks in fat cells, French study finds. Yahoo! News. September 11, 2002
| African meeting calls for focus on AIDS orphans. Yahoo! News. September 11, 2002
| New AIDS cases down 11% in the E.U. in 2001. Yahoo! News. September 11, 2002
| HIV could aid heart transplants. BBC News. September 10, 2002
| Alarm over HIV resistance. BBC News. September 10, 2002
| HIV infection rate pinpointed. BBC News. September 10, 2002
| Rising HIV 'must top public health agenda'. The Independent. September 10, 2002
| Immune Response CEO resigns. Los Angeles Times. September 10, 2002
| German expert fears increase in new AIDS cases. Yahoo! News. September 10, 2002
| Report: Gender impacts HIV blood levels. Yahoo! News. September 10, 2002
| CDC to open office to fight HIV/AIDS in the Caribbean. Sun-sentinel.com. September 10, 2002
| Russia sits on the edge of an epidemic. Los Angeles Times. September 9, 2002
| U.S. to provide AIDS assistance to Vietnam. San Francisco Chronicle. September 9, 2002
| Illegal bid to get chimps for HIV tests. AllAfrica.com. September 9, 2002
| China denies plans to make AIDS drugs that violate foreign patents. San Francisco Chronicle. September 9, 2002
| Group: Chinese AIDS activist in custody. Yahoo! News. September 8, 2002
| High speed condom to fight AIDS. BBC News. September 7, 2002
| AIDS debate fails to hit target at development summit. BMJ News. September 7, 2002
| China reports AIDS cases to reach 1 million this year. Boston Globe. September 7, 2002
| China faces up to AIDS epidemic. Miami Herald. September 7, 2002
| Microscience now able to deliver DNA vaccines orally. Yahoo! News UK & Ireland. September 6, 2002
| Missing Chinese AIDS worker being held by secret police, says friend, activists. Yahoo! News. September 6, 2002
| From cancer to AIDS: the RNAi revolution is gathering pace. The Independent. September 6, 2002
| Glaxo cuts AIDS drugs for poor. New York Times. September 5, 2002
| Man 're-infected with HIV'. BBC News. September 5, 2002
| Bush asks Congress for $200m to fight AIDS. Yahoo! News. September 5, 2002
| Biochemist rallies colleagues to publish results on the Web. San Francisco Chronicle. September 4, 2002
| Pacific youth warned on AIDS. BBC News. September 3, 2002
| Recommendations for the use of antiretroviral drugs in pregnant women. HIV/AIDS Treatment Information Service. September 3, 2002
| Fund AIDS fight not foreign debts, says UN adviser. Yahoo! News. September 1, 2002
| Honduras to compensate woman for HIV. CNN. September 1, 2002
| U.S. asks China about missing AIDS activist. Yahoo! News. August 31, 2002
| HIV targets more active human genes. Yahoo! News. August 31, 2002
| Gay bathhouses good targets for anti-HIV outreach. Yahoo! News. August 31, 2002
| Thai charity ditches AIDS 'cure'. BBC News. August 30, 2002
| Theory says chimps had AIDS epidemic. Boston Globe. August 30, 2002
| Research: HIV no bar to organ transplant success. Los Angeles Times. August 30, 2002
| UN seeks help from companies in war on HIV/AIDS. Financial Times. August 30, 2002
| AIDS fight called key in stopping poverty. Philadelphia Inquirer. August 30, 2002
| Summit accused of ignoring AIDS. Financial Times. August 30, 2002
| Botswana watches AIDS destroy economic success. San Francisco Chronicle. August 30, 2002
| U.N. launches program to spread AIDS awareness among seamen. Yahoo! News. August 30, 2002
| Chinese AIDS activist missing. Los Angeles Times. August 29, 2002
| Bill Gates foundation gives grants to low-tech efforts at HIV prevention. Yahoo! News. August 29, 2002
| Drug resistant HIV increasing in North America. British Medical Journal news. August 29, 2002
| More than 3,500 new HIV cases registered every month in Russia. Yahoo! News. August 28, 2002
| Diaphragm put to test against HIV. San Francisco Chronicle. August 28, 2002
| AIDS funding stalls in ravaged province. Boston Globe. August 27, 2002
| Syringe sale bill clears California assembly. Press release. August 27, 2002
| Dominica needs help in AIDS battle. Miami Herald. August 27, 2002
| UN says summit will focus on AIDS. Financial Times. August 26, 2002
| Doing something positive about HIV. Miami Herald. August 25, 2002
| Promising multi-strain HIV vaccine candidate emerges. Institute of Human Virology news. August 25, 2002
| AIDS scourge in rural China leaves villages of orphans. New York Times. August 25, 2002
| Row over HIV/Aids success story. AllAfrica.com. August 24, 2002
| African HIV vaccine due for final phase. AllAfrica.com. August 24, 2002
| CDC notes HIV risk for young, black gays. Yahoo! News. August 24, 2002
| People with HIV try alternative remedies. Yahoo! News. August 24, 2002
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More news headlines: This week | Last week | Search archive |
Latest Journal Headlines:
[What is this?]
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| Does patient sex affect human immunodeficiency virus levels?. Clinical Infectious Diseases. (Posted: September 10, 2002) | | Considerations and development of topical microbicides to inhibit the sexual transmission of HIV. Expert Opinion on Investigational Drugs. (Posted: September 7, 2002) | | Opportunistic infections in HIV-infected individuals: hepatitis C virus. Lancet. (Posted: September 7, 2002) | | NeuroAIDS: Effect of combination antiretroviral therapy on neurologic abnormalities. Journal of Pediatrics. (Posted: September 6, 2002) | | Long-term effects of intermittent interleukin 2 therapy in patients with HIV infection. Blood. (Posted: September 6, 2002) | | Potent and specific inhibition of HIV-1 replication by RNA interference. Journal of Virology. (Posted: September 4, 2002) | | T-cell response in rhesus macaques immunized with HIV gag DNA vaccines. Journal of Virology. (Posted: September 4, 2002) | | NeuroAIDS: Development of a human neuronal cell model for HIV-infected macrophage-induced neurotoxicity. Journal of Virology. (Posted: September 4, 2002) | | Continuing HIV transmission among injection drug users in Eastern Central Canada. Journal of Acquired Immune Deficiency Syndromes. (Posted: September 3, 2002) | | A randomized trial with low-dose prolonged intermittent interleukin-2 adjuvant therapy. The Journal of Infectious Diseases. (Posted: September 3, 2002) | | NeuroAIDS: Central nervous system damage, monocytes and macrophages, and neurological disorders in AIDS. Annual Review of Neuroscience. (Posted: September 3, 2002) | | NeuroAIDS: Correlates of independent HIV-1 replication in the CNS and of its control by antiretrovirals. Neurology. (Posted: September 3, 2002) | | Next generation DNA vaccines for HIV-1. Journal of Liposome Research. (Posted: September 3, 2002) | | Recruiting volunteers for a multisite phase I/II HIV preventive vaccine trial in Thailand. Journal of Acquired Immune Deficiency Syndromes. (Posted: September 3, 2002) | | Sexual behaviors in an urban bathhouse 15 years into the HIV epidemic. Journal of Acquired Immune Deficiency Syndromes. (Posted: September 3, 2002) | | NeuroAIDS: PCNA expression as a marker of perivascular macrophages in SIV encephalitis. American Journal of Pathology. (Posted: September 3, 2002) | | Increased peripheral expansion of naive CD4+T cells in vivo after IL-2 treatment of HIV patients. Proc. Natl. Acad. Sci. USA. (Posted: September 3, 2002) | | DNA vaccines encoding HIV-1 gp120 fusions with proinflammatory chemoattractants. Blood. (Posted: September 3, 2002) | | Clients of female sex workers in Nyanza province, Kenya — A core group in STD/HIV transmission. Sexually Transmitted Diseases. (Posted: August 29, 2002) | | Design and tests of an HIV vaccine. British Medical Bulletin. (Posted: August 29, 2002) | | Intention to notify sexual partners about potential HIV exposure among NYC STD clinics' clients. Sexually Transmitted Diseases. (Posted: August 29, 2002) | | Mathematical models of vaccination. British Medical Bulletin. (Posted: August 29, 2002) | | HIV-specific CD8 T-cell activity in uninfected injection drug users. AIDS. (Posted: August 24, 2002) | | HIV-1 envelope-CD4 receptor complexes elicit broadly cross-reactive neutralizing antibodies. Proc. Natl. Acad. Sci. USA. (Posted: August 24, 2002) |
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