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Severe CD4+ T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretroviral therapy Dandekar S, et al.
Journal of Virology
2003 Nov;77(21):11708-17
Link Here, they analyzed longitudinal jejunal biopsy samples from HIV-1-infected patients, during both primary and chronic stages of HIV-1 infection, prior to and following the initiation of highly active antiretroviral therapy (HAART) to determine the onset of CD4(+) T-cell depletion and the effect of HAART on the restoration of CD4(+) T cells in gut-associated lymphoid tissue (GALT). They found that severe depletion of intestinal CD4(+) T cells occurred during primary HIV-1 infection. Results demonstrate that near-complete restoration of mucosal immune system can be achieved by initiating HAART early in HIV-1 infection.
—Posted: December 3, 2003
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